Samantha Sky Shelton was born 15 November 1978 to director Christopher Stromme and Carol Stromme.She has three older sisters, Koren, Erin and fellow actress Marley Stromme.

Samantha studied acting while attending the North Carolina School of the Arts, and at the Los Angeles High School of the Arts.

Her debut was in the film Hairshirt as a waitress, before several television guest roles, including a recurring role on Judging Amy. She had a supporting role in White Oleander as a pregnant girl in foster care. In 2002, she guest starred on Charmed as a witch descendant, Selena. In 2003, she starred alongside her sister Marley in the independent film Moving Alan, and she played the best friend roles in Learning Curves and Shopgirl. She also played a receptionist in the indie hit Ellie Parker. Some of her scenes were cut, but can be found in the 'special features' section of the DVD.

In early 2006, she completed filming for the independent film Marcus, which is currently being distributed at film festivals and trying to secure a cinematic release. In 2006, she also starred in Monarch Cove, a TV series aired on Lifetime Network.

From 2001 to 2005, Shelton performed in the jazz cabaret act If all the stars were pretty babies with fellow actress Zooey Deschanel. She has launched three EPs: Are you kidding around, Cranky Moon and Sea Legs.

She currently resides in Los Angeles, California.