Baker has done voice work in video games for the Star Trek and X-Men and guest starred in television shows such as That '70s Show, Early Edition, Yes, Dear and among other series. She also starred in the short-lived 1996 sitcom The Last Frontier and voiced Lu Zhi in the 2010 game Age of Conan: Rise of the Godslayer.
Baker is also known to television audiences for her recurring roles as Hannah Webster in the first season of Charmed and as Ellen, the long-time friend of Grace Adler (Debra Messing) on Will & Grace, which she played since the show began in 1998 through to its last season in 2006. She is also known for providing the voice of Abby in the Nickelodeon animated series Back at the Barnyard.
In late 2008, Baker appeared on several episodes of Hannah Montana playing Mickey, a morning show host. She starred as Amy Duncan, the matriarch of the Duncan family on the Disney Channel original sitcom, Good Luck Charlie, which ran from 2010–2014.
In 2015, she starred in the Disney Channel Original Movie, Bad Hair Day, which she also produced. She plays Liz Morgan, a "down on her luck" cop who must get a priceless necklace by teaming up with high school senior, played by Laura Marano. In an interview with Variety, Baker said, "I wanted to executive produce because I wanted to see what it was like to build and fulfill a vision from the ground up, and since this was Disney Channel's first movie with an adult lead, I wanted that role to be protected and I wanted the movie to have my creative stamp on it." She also liked that she got to work on the Disney movie because it taps into her family unit fanbase. In 2016, she starred in the faith-based Christmas film, "Wish for Christmas".
- Shrunken Heads
- Leprachaun 3
- Breast Men
- Hannah Montana
- Will & Grace
- Good Luck Charlie
- X-Men Legends
- X-Men Legends II: Rise of the Apocalypse